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Professor Youngja Hwang Park, PhD. (박영자 교수)
Address: College of Pharmacy, Korea University, 2511 Sejong-ro, Sejong City, South Korea 339-700 주소: 세종특별자치시세종로 2511 고려대학교 약학대학 Tel.: +82-44-860-1621 Fax: +82-44-860-1606 E-mail: yjhwang@korea.ac.kr |
Education (학력)
Bachelor of Science in Pharmacy (학사) - Ehwa Women's University, Korea (이화여자대학교)
Master of Science in Pharmacy (석사) - University of Texas at Austin, USA
Doctor of Philosophy in Pharmacology and Toxicology (박사) - University of Texas at Austin, USA
Research Interest (주요연구분야)
Publications since 2009 (2009년 이후 주요 논문)
1. H.-W. Cho, S. B. Kim, M. K. Jeong, Y. Park, T. R. Ziegler, D. P. Jones : Genetic Algorithm-based feature selection in high-resolution NMR spectra. Expert Systems with Applications, 35, 967-975, 2008.
2. S. B. Kim, V. C. P. Chen, Y. Park, T. R. Ziegler, D. P. Jones: Controlling the false discovery rate for feature selection in high-resolution NMR spectra. Statistical Analysis and Data Mining, 1, 57-66, 2008.
3. H.-W. Cho, S. B. Kim, M. K. Jeong, Y. Park, N. Gletzu, T. R. Ziegler, D. P. Jones: Discovery of metabolite features for the modelling and analysis of high-resolution NMR spectra. International Journal of Data Mining and Bioinformatics. 2, 176-191, 2008
4. Y. Park, S.B. Kim, B. Wang, R. Blanco, N.-A. Le, S. Wu, C. J. Accardi, R.W. Alexander, T.R. Ziegler, D.P. Jones: Individual variation in macronutrient regulation measured by proton magnetic resonance spectroscopy of human plasma. Am. J. Physiol. Reg. Integr. Comp. Physiol. 297, 202-209, 2009
5. T. Yu, Y. Park, J.M. Johnson, D. P. Jones: apLCMS-adaptive processing of high resolution LC/MS data, Bioinformatics 25, 1930-1936, 2009
6. Y. Jung, Y. Park, D. P. Jones, B. Vidakovic . Scaling in 1H NMR spectra: An application in assessing the level of cysteine. J. Data Science, 8, 1-19, 2010.
7. Youngja Park, Thomas R. Ziegler, Nana Gletsu-Miller, Yongliang Liang, Tianwei Yu, Carolyn Jonas Accardi, and Dean P. Jones. Postprandial Cysteine/Cystine Redox Potential in Human Plasma Varies With Meal Content of Sulfur Amino Acids. J. Nutr. 140,760-765, 2010.
8. Y. O. Mannery, T. R. Ziegler, Y. Park, D. P. Jones: Oxidation of Plasma Cysteine/Cystine and GSH/GSSG Redox Potentials by Acetaminophen and Sulfur Amino Acid Insufficiency in Human s. J Pharmacol. Exptl. Therap, 333,939-47, 2010.
9. Y. O. Mannery, T. R. Ziegler, Y. Park, D. P. Jones: Acetaminophen Elimination Half-life in Humans is Unaffected by Short-Term Consumption of Sulfur Amino Acid-Free Diet. J Pharmacol. Exptl. Therap, 333, 948-53, 2010.
10. Jones DP, Park Y, Gletsu-Miller N, Liang Y, Yu T, Accardi CJ, Ziegler TR. Dietary sulfur amino acid effects on fasting plasma cysteine/cystine redox potential in humans, Nutrition, 27, 199-205, 2011.
11. Youngja Park, Dean P. Jones, Thomas R. Ziegler, Kichun Lee, Kavitha Kotha, Tianwei Yu, Greg S. Martin. Metabolic effects of albumin therapy in acute lung injury measured by 1H NMR spectroscopy of plasma: a pilot study. Crit. Care Med. 39, 1-6, 2011.
12. Youngja Park, Ngoc-Anh Le, Tianwei Yu, Fred Strobel, Nana Gletsu-Miller, Carolyn J. Accardi, Kichun S. Lee, Shaoxiong Wu, Thomas R. Ziegler and Dean P. Jones. A Sulfur Amino Acid-Free Meal Increases Plasma Lipids in Humans. J. Nutr, 141, 1424-31, 2011
13. Soltow QA, Strobel FH, Mansfield KG, Wachtman L, Park Y, Jones DP. 2011. High-performance metabolic profiling with dual chromatography Fourier transform mass spectrometry (DC-FTMS) for study of the exposome. Metabolomics. DOI 10.1007/s11306-011-0332-132.
14. Anna J. Blackstock, Amita K. Manatunga, Youngja Park, Dean P. Jones, Tianwei Yu. Clustering Based on Periodicity in High-Throughput Time Course Data. Statistical Analysis and Data Mining 4: 579–589, 2011
15. Sachin S. Kunde, James R. Roede, Miriam B. Vos, Michael L. Orr, Young-Mi Go, Youngja Park, Thomas R. Ziegler and Dean P. Jones. Hepatic Oxidative Stress in Frucose-Induced Fatty Liver Is Not Caused by Sulfur Amino Acid Insufficiency. Nutrients, 3, 987-1002, 2011
16. Youngja H. Park, Kichun Lee, Quinlyn A. Soltow, Frederick H. Strobel, Kenneth L. Brigham, Richard E.Parker, Mark E. Wilson, Roy L. Sutliff, Keith G. Mansfield, Lynn M. Wachtman, Thomas R. Ziegler and Dean P. Jones. High performance metabolic profiling of plasma from seven mammalian species for simultaneous environmental chemical surveillance and bioeffect monitoring Toxicology, 295, 47-55, 2012.
17. Youngja Park, Tiejun Zhao, Nana Gletsu Miller, Seoung Bum Kim, Carolyn Jonas Accardi, Thomas R. Ziegler, Xiaoping Hu, and Dean P. Jones. Increased glutamate in human midbrain and correlation with plasma cystine after three days on sulfur amino acid-free diet: A pilot magnetic resonance spectroscopy study. Nutrition, 28, 235-241, 2012
18. James R. Roede, Youngja Park, Shuzhao Li, Frederick H. Strobel and Dean P. Jones. Detailed Mitochondrial Phenotyping by High Resolution Metabolomics. PLOS One, 2012;7(3):1-8: e33020. Epub 2012 Mar 6.
19. Jones DP, Park Y, Ziegler TR. Nutritional metabolomics: progress in addressing complexity in diet and health, Annu Rev Nutr, 32, 183-202, 2012
20. Yu, Tianwei; Park, Youngja; Li, Shuzhao; Jones, Dean, Hybrid feature detection and information accumulation using high-resolution LC-MS metabolomics data. J. Proteome Res, 12(3), 1419-27, 2013.
21. Jesse F. Gregory III, Youngja Park, Yvonne Lamers, Nirmalya Bandyopadhyay, Yueh- Yun Chi, Kichun Lee, Steven Kim, Vanessa da Silva, Sanjay Ranka, Tamer Kahveci, Keith E. Muller, James R. Bain, Christopher B. Newgard, Peter W. Stacpoole, and Dean P. Jones, Metabolomic Analysis Reveals Extended Metabolic Consequences of Marginal Vitamin B-6 Deficiency in Healthy Human Subjects, PLOS One, 8(6), 1-9, e63544, 2013
22. Shuzhao Li, Youngja Park, Sai Duraisingham, Frederick H Strobe, Nooruddin Khan, Quinlyn A Soltow, Dean P Jones, Bali Pulendran, Predicting network activity from high throughput metabolomics, PLOS Comp Biol, 9(7), 1-11, e1003123, 2013
23. Youngja Park, Kichun Lee, Gautam Hebbard, Greg S. Martin, Thomas R. Ziegler, Brani Vidakovic, Dean P Jones, Multifractal analysis for nutritional assessment, PLOS One, 8(8), 1-9, e69000, 2013
24. Melissa, P. Osborn, Youngja Park, Megan B. Parks, L. Goodwin Burgess, Karan Uppal, Kichun Lee, Dean P. Jones, Milam A. Brantley Jr., Metabolomics-wide association study of nevascular age-realted macular degeneration, PLOS One, 8(8), 1-9, e72737, 2013
25. Roede JR, Uppal K, Park Y, Lee K, Tran V, Walker D, Strobel FH, Rhodes SL, Ritz B, Jones D P, Serum metabolomics of slow vs. rapid motor progression Parkinson's disease: a pilot study. PLoS One. 2013 Oct 22;8(10):e77629. doi: 10.1371/journal.pone.0077629.
26. Rajesh Ravindran, Nooruddin Khan, Helder I Nakaya, Shuzhao Li, Jens Loebbermannn, Mohan S Maddur, Youngja Park, Dean P Jones, Pascal Chappert, Jean Davoust, David S Weiss, Herbert W Virgin, David Ron and Bali Pulendran. Vaccine activation of the nutrient sensor GCN2 in dendritic cells enhances antigen presentation. Science, 2014, 343, 313-317
27. Fitzpatrick AM, Park Y, Brown LA, Jones DP. Children with severe asthma have unique oxidative stress associated metabolomic profiles. J Allergy Clin Immunol. 2014 Jan;133(1):258-261.
28. Cribbs SK, Park Y, Guidot D, Martin G, Brown LA, Lennox J, Jones D. Metabolomics of bronchoalveolar lavage differentiate healthy HIV-1 infected subjects from controls. AIDS Res Hum Retroviruses. 2014, 6, 579-585
29. D.C. Neujahr, K. Uppal, S.D. Force, F. Fernandez, C. Lawrence, A. Pickens, R. Bag, C. Lockard, A.D. Kirk, V. Tran, K. Lee, D.P. Jones, and Y Park: Bile acid aspiration associated with lung chemical profile linked to other biomarkers of injury after lung transplantation. Am J. Tranplant, 2014, 14, 841-848
30. Katz, M., Won, S. J., Park, Y., Orr, A., Jones, D. P., Swanson, R. A., & Glass, G. A. (2015). Cerebrospinal fluid concentrations of N-acetylcysteine after oral administration in Parkinson's disease. Parkinsonism & related disorders.
31. Y.H. Park, Y. Shi, B. Liang, C.A.D. Medriano, Y.H. Jeon, E. Torres, and D.P. Jones. High-resolution metabolomics to discover potential parasite-specific biomarkers in a Plasmodium falciparum erythrocytic stage culture system. Malaria Journal, 2015, 14(1), 122.
Bachelor of Science in Pharmacy (학사) - Ehwa Women's University, Korea (이화여자대학교)
Master of Science in Pharmacy (석사) - University of Texas at Austin, USA
Doctor of Philosophy in Pharmacology and Toxicology (박사) - University of Texas at Austin, USA
Research Interest (주요연구분야)
- Identification of novel biomarkers in high risk diseases including parkinson’s disease, malaria, and cardiovascular disease using LC-LTQ-Velos Orbitrap and LTQ-FT-ICR mass spectrometers.
- High performance metabolic profiling with bioinformatics on large data sets including false discovery rate, principal component analysis, partial least square-discriminant analysis, modulated modularity clustering and pathway mapping to discriminate metabolic profiles between disease and health to improve understanding of human health and management and treatment of disease.
- Nutritional metabolomics to determine time-dependent metabolic fingerprints using 1H nuclear magnetic resonance spectroscopy and non-invasive metabolomics using magnetic resonance spectroscopy.
- Using HPLC, the measurement of oxidative stress biomarkers including GSH/GSSG, Cyteine/Cystine.
Publications since 2009 (2009년 이후 주요 논문)
1. H.-W. Cho, S. B. Kim, M. K. Jeong, Y. Park, T. R. Ziegler, D. P. Jones : Genetic Algorithm-based feature selection in high-resolution NMR spectra. Expert Systems with Applications, 35, 967-975, 2008.
2. S. B. Kim, V. C. P. Chen, Y. Park, T. R. Ziegler, D. P. Jones: Controlling the false discovery rate for feature selection in high-resolution NMR spectra. Statistical Analysis and Data Mining, 1, 57-66, 2008.
3. H.-W. Cho, S. B. Kim, M. K. Jeong, Y. Park, N. Gletzu, T. R. Ziegler, D. P. Jones: Discovery of metabolite features for the modelling and analysis of high-resolution NMR spectra. International Journal of Data Mining and Bioinformatics. 2, 176-191, 2008
4. Y. Park, S.B. Kim, B. Wang, R. Blanco, N.-A. Le, S. Wu, C. J. Accardi, R.W. Alexander, T.R. Ziegler, D.P. Jones: Individual variation in macronutrient regulation measured by proton magnetic resonance spectroscopy of human plasma. Am. J. Physiol. Reg. Integr. Comp. Physiol. 297, 202-209, 2009
5. T. Yu, Y. Park, J.M. Johnson, D. P. Jones: apLCMS-adaptive processing of high resolution LC/MS data, Bioinformatics 25, 1930-1936, 2009
6. Y. Jung, Y. Park, D. P. Jones, B. Vidakovic . Scaling in 1H NMR spectra: An application in assessing the level of cysteine. J. Data Science, 8, 1-19, 2010.
7. Youngja Park, Thomas R. Ziegler, Nana Gletsu-Miller, Yongliang Liang, Tianwei Yu, Carolyn Jonas Accardi, and Dean P. Jones. Postprandial Cysteine/Cystine Redox Potential in Human Plasma Varies With Meal Content of Sulfur Amino Acids. J. Nutr. 140,760-765, 2010.
8. Y. O. Mannery, T. R. Ziegler, Y. Park, D. P. Jones: Oxidation of Plasma Cysteine/Cystine and GSH/GSSG Redox Potentials by Acetaminophen and Sulfur Amino Acid Insufficiency in Human s. J Pharmacol. Exptl. Therap, 333,939-47, 2010.
9. Y. O. Mannery, T. R. Ziegler, Y. Park, D. P. Jones: Acetaminophen Elimination Half-life in Humans is Unaffected by Short-Term Consumption of Sulfur Amino Acid-Free Diet. J Pharmacol. Exptl. Therap, 333, 948-53, 2010.
10. Jones DP, Park Y, Gletsu-Miller N, Liang Y, Yu T, Accardi CJ, Ziegler TR. Dietary sulfur amino acid effects on fasting plasma cysteine/cystine redox potential in humans, Nutrition, 27, 199-205, 2011.
11. Youngja Park, Dean P. Jones, Thomas R. Ziegler, Kichun Lee, Kavitha Kotha, Tianwei Yu, Greg S. Martin. Metabolic effects of albumin therapy in acute lung injury measured by 1H NMR spectroscopy of plasma: a pilot study. Crit. Care Med. 39, 1-6, 2011.
12. Youngja Park, Ngoc-Anh Le, Tianwei Yu, Fred Strobel, Nana Gletsu-Miller, Carolyn J. Accardi, Kichun S. Lee, Shaoxiong Wu, Thomas R. Ziegler and Dean P. Jones. A Sulfur Amino Acid-Free Meal Increases Plasma Lipids in Humans. J. Nutr, 141, 1424-31, 2011
13. Soltow QA, Strobel FH, Mansfield KG, Wachtman L, Park Y, Jones DP. 2011. High-performance metabolic profiling with dual chromatography Fourier transform mass spectrometry (DC-FTMS) for study of the exposome. Metabolomics. DOI 10.1007/s11306-011-0332-132.
14. Anna J. Blackstock, Amita K. Manatunga, Youngja Park, Dean P. Jones, Tianwei Yu. Clustering Based on Periodicity in High-Throughput Time Course Data. Statistical Analysis and Data Mining 4: 579–589, 2011
15. Sachin S. Kunde, James R. Roede, Miriam B. Vos, Michael L. Orr, Young-Mi Go, Youngja Park, Thomas R. Ziegler and Dean P. Jones. Hepatic Oxidative Stress in Frucose-Induced Fatty Liver Is Not Caused by Sulfur Amino Acid Insufficiency. Nutrients, 3, 987-1002, 2011
16. Youngja H. Park, Kichun Lee, Quinlyn A. Soltow, Frederick H. Strobel, Kenneth L. Brigham, Richard E.Parker, Mark E. Wilson, Roy L. Sutliff, Keith G. Mansfield, Lynn M. Wachtman, Thomas R. Ziegler and Dean P. Jones. High performance metabolic profiling of plasma from seven mammalian species for simultaneous environmental chemical surveillance and bioeffect monitoring Toxicology, 295, 47-55, 2012.
17. Youngja Park, Tiejun Zhao, Nana Gletsu Miller, Seoung Bum Kim, Carolyn Jonas Accardi, Thomas R. Ziegler, Xiaoping Hu, and Dean P. Jones. Increased glutamate in human midbrain and correlation with plasma cystine after three days on sulfur amino acid-free diet: A pilot magnetic resonance spectroscopy study. Nutrition, 28, 235-241, 2012
18. James R. Roede, Youngja Park, Shuzhao Li, Frederick H. Strobel and Dean P. Jones. Detailed Mitochondrial Phenotyping by High Resolution Metabolomics. PLOS One, 2012;7(3):1-8: e33020. Epub 2012 Mar 6.
19. Jones DP, Park Y, Ziegler TR. Nutritional metabolomics: progress in addressing complexity in diet and health, Annu Rev Nutr, 32, 183-202, 2012
20. Yu, Tianwei; Park, Youngja; Li, Shuzhao; Jones, Dean, Hybrid feature detection and information accumulation using high-resolution LC-MS metabolomics data. J. Proteome Res, 12(3), 1419-27, 2013.
21. Jesse F. Gregory III, Youngja Park, Yvonne Lamers, Nirmalya Bandyopadhyay, Yueh- Yun Chi, Kichun Lee, Steven Kim, Vanessa da Silva, Sanjay Ranka, Tamer Kahveci, Keith E. Muller, James R. Bain, Christopher B. Newgard, Peter W. Stacpoole, and Dean P. Jones, Metabolomic Analysis Reveals Extended Metabolic Consequences of Marginal Vitamin B-6 Deficiency in Healthy Human Subjects, PLOS One, 8(6), 1-9, e63544, 2013
22. Shuzhao Li, Youngja Park, Sai Duraisingham, Frederick H Strobe, Nooruddin Khan, Quinlyn A Soltow, Dean P Jones, Bali Pulendran, Predicting network activity from high throughput metabolomics, PLOS Comp Biol, 9(7), 1-11, e1003123, 2013
23. Youngja Park, Kichun Lee, Gautam Hebbard, Greg S. Martin, Thomas R. Ziegler, Brani Vidakovic, Dean P Jones, Multifractal analysis for nutritional assessment, PLOS One, 8(8), 1-9, e69000, 2013
24. Melissa, P. Osborn, Youngja Park, Megan B. Parks, L. Goodwin Burgess, Karan Uppal, Kichun Lee, Dean P. Jones, Milam A. Brantley Jr., Metabolomics-wide association study of nevascular age-realted macular degeneration, PLOS One, 8(8), 1-9, e72737, 2013
25. Roede JR, Uppal K, Park Y, Lee K, Tran V, Walker D, Strobel FH, Rhodes SL, Ritz B, Jones D P, Serum metabolomics of slow vs. rapid motor progression Parkinson's disease: a pilot study. PLoS One. 2013 Oct 22;8(10):e77629. doi: 10.1371/journal.pone.0077629.
26. Rajesh Ravindran, Nooruddin Khan, Helder I Nakaya, Shuzhao Li, Jens Loebbermannn, Mohan S Maddur, Youngja Park, Dean P Jones, Pascal Chappert, Jean Davoust, David S Weiss, Herbert W Virgin, David Ron and Bali Pulendran. Vaccine activation of the nutrient sensor GCN2 in dendritic cells enhances antigen presentation. Science, 2014, 343, 313-317
27. Fitzpatrick AM, Park Y, Brown LA, Jones DP. Children with severe asthma have unique oxidative stress associated metabolomic profiles. J Allergy Clin Immunol. 2014 Jan;133(1):258-261.
28. Cribbs SK, Park Y, Guidot D, Martin G, Brown LA, Lennox J, Jones D. Metabolomics of bronchoalveolar lavage differentiate healthy HIV-1 infected subjects from controls. AIDS Res Hum Retroviruses. 2014, 6, 579-585
29. D.C. Neujahr, K. Uppal, S.D. Force, F. Fernandez, C. Lawrence, A. Pickens, R. Bag, C. Lockard, A.D. Kirk, V. Tran, K. Lee, D.P. Jones, and Y Park: Bile acid aspiration associated with lung chemical profile linked to other biomarkers of injury after lung transplantation. Am J. Tranplant, 2014, 14, 841-848
30. Katz, M., Won, S. J., Park, Y., Orr, A., Jones, D. P., Swanson, R. A., & Glass, G. A. (2015). Cerebrospinal fluid concentrations of N-acetylcysteine after oral administration in Parkinson's disease. Parkinsonism & related disorders.
31. Y.H. Park, Y. Shi, B. Liang, C.A.D. Medriano, Y.H. Jeon, E. Torres, and D.P. Jones. High-resolution metabolomics to discover potential parasite-specific biomarkers in a Plasmodium falciparum erythrocytic stage culture system. Malaria Journal, 2015, 14(1), 122.
